Retatrutide

Product Overview

Retatrutide is a synthetic 39-amino-acid peptide amide featuring multiple strategic structural modifications. The sequence incorporates non-canonical amino acid residues (Aib) at positions 2 and 13, a C20 fatty diacid moiety conjugated via gamma-glutamic acid and AEEA (aminoethoxyethoxyacetic acid) linkers, and a C-terminal amidation.

Technical Specifications

Structural Context

Retatrutide is a 39-amino-acid peptide amide incorporating multiple structural features that distinguish it from standard amino acid configurations. The presence of non-canonical Aib (α-aminoisobutyric acid) residues at positions 2 and 13 introduces conformational constraint to the peptide backbone, restricting flexibility and providing a defined structural architecture. The C20 fatty diacid moiety—conjugated via a gamma-glutamic acid spacer and two AEEA linkers—contributes to the molecule’s amphipathic character. The C-terminal amidation provides a defined structural endpoint, while the sequence includes a proline-rich region (positions 31-39 containing three proline residues) that introduces distinct backbone dynamics. The incorporation of multiple charged residues (Aspartic Acid, Glutamic Acid, Lysine) alongside hydrophobic residues (Leucine, Isoleucine, Valine, Phenylalanine, Tryptophan) and polar residues creates a complex polarity profile. This architecture makes the compound suitable for analytical method development, chromatographic reference studies, and stability assessments in controlled laboratory environments.

Handling and Storage

The peptide is supplied in lyophilized (freeze-dried) powder form. For optimal stability, storage at or below -20°C is recommended. Protect from repeated freeze-thaw cycles and prolonged exposure to light, heat, and moisture.